Call for Papers

The International Workshop of Machine Learning in Clinical Neuroimaging (, a satellite event of MICCAI (, calls for original papers in the field of clinical neuroimaging data analysis with machine learning. The two tracks of the workshop include methodological innovations as well as clinical applications. This highly interdisciplinary topic provides an excellent platform to connect researchers of varying disciplines and to collectively advance the field in multiple directions.

In the machine learning track, we seek novel contributions that address current methodological gaps in analyzing high-dimensional, longitudinal, and heterogeneous clinical neuroscientific data using stable, scalable, and interpretable machine learning models. Topics of interest include but are not limited to:

  • Big data
  • Spatio-temporal brain data analysis
  • Structural data analysis
  • Graph theory and complex network analysis
  • Longitudinal data analysis
  • Model stability and interpretability
  • Model scalability in large neuroimaging datasets
  • Multi-source data integration and multi-view learning
  • Multi-site data analysis, from preprocessing to modeling
  • Domain adaptation, data harmonization, and transfer learning in neuroimaging
  • Unsupervised methods for stratifying brain disorders
  • Deep learning in clinical neuroimaging
  • Model uncertainty in clinical predictions

In the clinical neuroimaging track, the applications of existing machine learning algorithms are evaluated to move towards precision medicine for complex brain disorders. The discovery of biological markers in medicine is an important challenge across different fields and various experimental procedures and designs are used to detect biological signatures that can be utilized for improvement in diagnostic, treatment, or for other beneficial ends. However, for most complex brain disorders, we do not have reliable biomarkers today. The application of advanced machine learning methods may help to reach this goal. Therefore, we invite the community to submit conference contributions on machine learning approaches with the goal to improve our understanding of complex brain disorders, moving the field closer towards precision medicine. Topics of interest include but are not limited to:

  • Biomarker discovery 
  • Refinement of nosology and diagnostics 
  • Biological validation of clinical syndromes 
  • Treatment outcome prediction 
  • Course prediction 
  • Analysis of wearable sensors
  • Neurogenetics and brain imaging genetics
  • Mechanistic modeling
  • Brain aging
  • The presentation of clinical neuroimaging databases to stimulate developments in machine learning

Submission Process:

The workshop seeks high-quality, original, and unpublished work that addresses one or more challenges described above. Papers should be submitted electronically in Springer Lecture Notes in Computer Science (LCNS) style (see for detailed author guidelines) using the CMT system at The page limit is 8-pages (text, figures, and tables) plus up to 2-pages of references. We review the submissions in a double-blind process. Please make sure that your submission is anonymous. Accepted papers will be published in a joint proceeding with the MICCAI 2021 conference.

MLCN Special Issue at the MELBA journal:

This year, we will invite the top accepted papers to submit an extended version of their contribution to the MLCN special issue at the Journal of Machine Learning for Biomedical Imaging (MELBA). The invited papers will go through an independent review process by the journal.

Donders Best Paper Award:

This year the MLCN’s best paper award is sponsored by Donders Institute. All MLCN accepted papers will be eligible for the best paper award. The recipient of the award will be chosen by the MLCN scientific committee based on the scientific quality, novelty, and clarity of contributions. The winner will be announced at the end of the workshop and will receive 500 USD honorarium.

Important Dates:

  • Paper submission deadline: June 25, 2021, July 5, 11:59 PM Pacific Time
  • Notification of Acceptance: July 26, 2021
  • Camera-ready Submission: Aug 6, 2021
  • Workshop Date: September 27, 2021

Camera-ready Submission Instructions:

We follow the same procedure as MICCAI 2021 for camera-ready submission available at this link. Camera-ready material must be submitted by Friday, Aug 6, 2021. As described below, all the files must be uploaded to the submission site as a single zipped file of 350 MB or less (CMT system limit). Please submit your file via the “submit camera-ready file” link in your CMT user dashboard on

  • The authors must address the minor changes provided by the comments from reviewers ; please include a file entitled ‘Changes after review’ with a bulleted list of the modifications to the paper.
  • Identify ONE corresponding author, who must be available to carry out a proof check of the paper. Springer will contact the corresponding author approximately 3 weeks before the conference and the corresponding author will only be given a 72-hour timeslot to do so. See the FAQ page for answers related to multiple corresponding authors.
  • Copyright form available at this link must be signed by the corresponding author of the paper. Digital signature is not acceptable.
  • The camera-ready copy with all figures and the signed copyright form must be uploaded to the paper submission system within the single zip file; See the checklist below.
  • Each paper must be associated with a unique MLCN 2021 registration. Authors can present multiple papers with a single registration only if they are first authors on all papers.

The proceedings will be published as Lecture Notes in Computer Science (LNCS) in both electronic and paper versions by Springer. Please read carefully the information for authors from Springer. You must use the LNCS templates (LaTeX2e or Word) available on the Springer website to prepare your paper. The templates are also available in Overleaf.

To accommodate changes requested by the reviewers while also still accommodating additional content that Springer will add to your paper to link to your supplementary material (potentially putting your paper over the original 10-page limit), we will allow your paper to expand to 8½ pages (including figures and tables) + 2 pages for references, leaving room for additional Springer content/formatting on the bottom half of page 11. Note that since Springer will re-set your paper with the formatting rules we specified, it is still extremely important that you strictly adhere to the guidelines (i.e., no spaces, no modified margins, no vertical spacing adjustments, no font adjustments, etc.). The program chairs reserve the right to reject papers that are over the 10½ -page limit in the final version, or to reject those that have modified formatting commands in the Springer templates.

All figures are printed in black and white. Colored figures remain in color in the online version. Please make sure that any colored figures are comprehensible in black and white. Springer does not support color in text, tables or in equations.

Please ensure that Springer format for bibliographical references is strictly enforced.

Please make sure that if the same author appears on multiple papers their name appears in the same form on all papers, and is consistent with the form used in the author list you submitted to CMT when you registered your paper. Please make sure the order of the authors on your paper is the same as is entered into CMT.

If you use LaTeX, please insert a line % index{Last Name, First Name} for every author of the paper, right after the author{} command. We will use these to create an author index in the proceedings. We need your help to make sure we parse authors’ names into the last name and the first name correctly. This is particularly important for those authors with more than two words in their full names, making such parsing ambiguous.

The submission site will ask you to upload a single .zip file of your submission. Please zip all your files, including the digital copy of the signed copyright form, and name the .zip file using your paper submission ID (for example:, where 12 is your paper ID number).

Please include the following files in the .zip file:

  • If using LaTeX, include LaTeX2e files (*.tex) for the text and PS/EPS/JPG/PDF/PNG files for all figures and movies following the Embedding a video section below. Include your .bib file. Please use consistent names for your source files: paperXX.pdf, paperXX.tex, where XX is your paper ID;
  • If using Word, simply upload the Word file
  • Any additional style files and fonts you used, together with your source files that are not generally available at CTAN;
  • Final PDF file of the paper (for reference). Please do not include earlier versions.
  • RTF files if you are using a word-processing system other than LaTeX/TeX or Microsoft Word;
  • The LNCS copyright form, which must be signed by the corresponding author on behalf of all authors. Conference name, “MLCN 2021”, and the volume editors’ names are already entered for you. Copyright forms must be signed in wet-ink. Digital signature is not acceptable. Please scan your signed copyright form and save it as a JPG or PDF file.

Camera-ready Submission checklist:

  • The title of your paper on the CMT form matches the one you have in your manuscript file
  • Names and affiliations of ALL authors are listed on BOTH CMT form and in your manuscript file
  • Names of ALL authors are spelled correctly and capitalized properly on BOTH CMT form and in your manuscript file
  • I have designated ONE corresponding author on the camera-ready submission form. Springer will be contacting the corresponding author approximately 3 weeks before the conference to carry out a final proof check of the paper.
  • I have included a copy-right transfer form signed by the corresponding author. (Digital signature is not acceptable.)
  • I have included the final PDF of my camera-ready submission in my zip folder
  • I have used consistent names for my source files: paperXXX.pdf, paperXXX.tex, where XXX is your MLCN 2021 paper ID;
  • (Latex user only) I have included %index{Last Name, First Name} for every author of the paper, right after the author{} command.
  • (Latex user only) I have included source files, including the .tex, .bib (if using BibTex), and figure files.
  • (Word user only) I have included my word file (.docx)
  • I have named my .ZIP file using the format:, where Num is your paper ID.
  • One of the authors has registered for the conference and I have included the registration number on the camera-ready submission form.
  • I understand that once a paper has been delivered to Springer, the paper and author list can not be altered